A recent study suggests that people who stop using new GLP-1 drugs like Wegovy and Mounjaro can put back on shed pounds far faster than those who halt conventional lifestyle programs.
Findings released in a major medical journal shows that while overweight individuals can lose a large proportion of their total mass while on the medication, the weight returns at an average rate of nearly a kilo each month upon discontinuation.
"Users purchasing such drugs must be aware of the risk of fast weight regain when the treatment concludes," stated lead investigator Dr. Susan Jebb.
This pace of regain implies a return to starting weight within about one and a half years.
Analyzing Therapies
The analysis, which examined dozens of trials involving over 9,000 of participants, compared the outcomes of these new drugs with older methods.
Scientists note that people who lose weight through dieting generally have a less rapid weight regain—around 100 grams monthly—after stopping.
Understanding the Fast Regain
Experts believe the way of the drugs explains the amplified rebound.
These medications imitate a natural hormone called GLP-1, which helps regulate appetite.
"Long-term administration of the hormone concentrations several times higher than the body's typical production might result in the body to produce less of its endogenous hormone, and may also diminish sensitivity to its effects," noted Dr. Adam Collins, a dietetics expert.
"Discontinuation of this medication means hunger is unsuppressed, making binge eating a significant risk."
An Ongoing Issue?
Health authorities recommend the injections for people with weight-linked health risks, alongside prescribed lifestyle changes.
A number of clinicians contend that, given the high risk of relapse, the treatment might need to be life-long.
This opinion is reinforced by drug manufacturers, who state that the findings "highlight the persistent character of excess weight," comparing it to managing conditions like high blood pressure.
Patient Testimonies
Users who have come off the medication describe a sudden return of cravings.
"I experienced a trigger activating and you're instantly ravenous," described a patient.
This difficulty is exacerbated if users have not developed sustainable dietary or behavioural changes during treatment.
Significant Adoption
Recent estimates suggest that a significant number of adults in the UK have used these injections in the past year, with interest continuing to grow.
- Use is greater among women compared to men.
- The middle-aged demographic shows the highest usage rates.
- Many access the drugs through private prescriptions rather than the NHS.
Ultimately, researchers stress that while these medications are effective tools for shedding pounds, they are not a magic solution and lasting health benefits relies on ongoing lifestyle support.
